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Gelatin or cellulose capsules? Which to choose?

27 styczeń 2025

Selecting the right type of capsules is one of the first steps when introducing a dietary supplement or pharmaceutical product to the market. This decision affects not only the bioavailability of active substances, but also the comfort of use and the target group. To consciously choose the best solution, it is worth analyzing the advantages and limitations of each available option.

Dietary supplements in capsules

Dietary supplements available in capsules have gained immense popularity, mainly due to the convenience of use and precise dosing. They allow for easy intake of appropriate amounts of nutrients without the need to weigh or mix them, which is crucial for the effectiveness of supplementation.

Why are dietary supplements in capsules a popular solution?

One of the key advantages of capsules is the ability to mask the taste and smell of the ingredients they contain. Some nutrients, especially plant extracts, minerals, or oils, can have an intense and often unpleasant aroma that discourages use. Encapsulation effectively eliminates this problem, increasing the comfort of supplementation. In addition, the wide range of capsule sizes makes it possible to precisely adjust the portion size to individual needs, which is important both for people using small doses and for those who require a larger amount of a given ingredient.

Capsules (both gelatin and cellulose) are also exceptionally versatile, as they allow not only powders to be enclosed, but also liquid or oily preparations, which significantly broadens the scope of their applications. Thanks to this, they can contain vitamins and minerals as well as fatty acids, probiotics, or plant extracts. Their rapid and effective dissolution in the digestive system contributes to better absorption of active ingredients, which in turn translates into greater supplementation efficiency.

Thanks to these properties, capsules are one of the most functional and comfortable ways to take supplements, providing effectiveness and convenience both to health-conscious individuals and to those seeking simple solutions to support their daily diet.

Gelatin capsules

Gelatin capsules are flexible shells with precisely controlled physical and chemical properties, designed to effectively enclose active substances. Thanks to their versatile structure, they can contain different forms of ingredients—powders, granules, suspensions, and solutions. Their main function is to protect the contents from external factors such as moisture or light.

Structure of gelatin capsules

Gelatin capsules consist of a shell and a filling, and their design is intended to ensure tightness, protection of active substances, and optimal conditions for their release in the body.

The capsule shell is made mainly from animal gelatin, i.e., hydrolyzed collagen, which gives it the appropriate structure. In addition, glycerol, acting as a plasticizer, and water are added to provide elasticity to the coating. In some cases, colorants and stabilizing substances are also used, which can improve capsule durability and facilitate identification.

Both transparent gelatin capsules and colored variants are available, covering various colors such as white, red, green, blue, pink, or black. Individual colors may indicate specific ingredients or dosing.

Thanks to their simple structure, gelatin capsules minimize the risk of interactions between the shell and the active substance, making them safe and widely used in the pharmaceutical and supplement industries. Their tightness protects the contents from moisture, oxidation, and other external factors, allowing the preparation to maintain stability and high quality for a long time.

Features of gelatin capsules

Gelatin capsules are produced mainly from natural animal-derived ingredients such as bones, connective tissue, or skin. They have no taste, smell, or color, which makes them a neutral carrier for various substances. Due to their properties, they are well tolerated by the body and easy to swallow.

One of the most important features of gelatin capsules is their ability to precisely release substances in the digestive system. Depending on the composition and type of capsule, they can dissolve in the stomach or intestines after a specific time, which allows for optimal absorption of nutrients.

Advantages of gelatin capsules

Gelatin capsules have many advantages that make them a popular choice in both the pharmaceutical industry and in the production of dietary supplements. Their properties affect supplementation effectiveness and ease of use.

  • One of the key advantages of gelatin capsules is the rapid release of active substances in the digestive system, which allows for efficient absorption by the body. At the same time, their shell provides effective protection of the contents against external factors such as moisture, oxygen, or light, which increases the stability and durability of the enclosed substances.
  • Another advantage is the ability to adjust the rate of ingredient release—depending on the type of coating, capsules can dissolve immediately or gradually, allowing controlled release of active substances. In addition, gelatin capsules are highly flexible in formulation because they can be filled with a variety of substances, including powders, granules, solutions, or suspensions.
  • Thanks to their smooth surface, gelatin capsules are easy to swallow, which is important for people who have difficulty taking tablets. They also effectively mask the taste and smell of medicinal substances, which significantly improves comfort of use. Precise dosing is another benefit, as each capsule contains an exact amount of active ingredients.
  • Gelatin capsules are also relatively inexpensive to produce, making them a cost-effective solution on a mass scale. Moreover, pharmaceutical gelatin itself has certain health-promoting properties, as it contains protein, minerals, and vitamins that can support the body’s functioning.

Disadvantages of gelatin capsules

Despite their numerous advantages, gelatin capsules also have certain limitations. First of all, they are a product of animal origin, which means they are not suitable for vegans and vegetarians. In addition, the protein contained in gelatin can, in a very small group of people, cause liver or kidney problems; therefore, in some cases caution in their use is necessary.

Cellulose capsules

Cellulose capsules, often referred to as vegan capsules, are made from plant fibers, making them an excellent alternative to traditional gelatin capsules. Thanks to their natural origin, they are fully suitable for vegans and vegetarians, as well as for people avoiding animal products for religious or health reasons.

Similar to gelatin capsules, cellulose capsules have no taste, smell, or color, so they do not affect the properties of the substances being taken. Due to their neutrality, they are readily used in the supplement and pharmaceutical industries, especially in products aimed at people seeking natural solutions.

Thanks to their plant origin, cellulose capsules are characterized by resistance to moisture, which increases the stability of the substances stored in them. Moreover, their structure allows for gradual and controlled release of active ingredients, affecting better absorption of certain preparations. These properties make cellulose capsules increasingly popular in the market for dietary supplements and pharmaceutical products.

What binds cellulose capsules?

For cellulose capsules to function effectively, an appropriate binder must be used to ensure their durability and stability. Traditionally, sucrose, starch, and gelatin were used for this purpose, but advances in pharmaceutical technology have led to the introduction of more modern substances.

Today, plant-derived polymers are increasingly used, including cellulose derivatives and polyvinylpyrrolidone, which have better adhesive properties. Thanks to them, capsules are more resistant to moisture, have higher mechanical stability, and can be tailored for controlled release of active substances.

The use of modern binders makes cellulose capsules even more versatile, and their composition can be entirely free of animal substances, making them an ideal choice for people seeking vegan and eco-friendly solutions in supplementation and pharmacy.

Advantages of cellulose capsules

Due to their properties, cellulose capsules offer a range of benefits that make them an attractive choice for many consumers.

  • One of the key strengths of cellulose capsules is their universal application, especially for liquid and oily supplements. Compared to gelatin capsules, they show better stability, which allows for longer storage of products without the risk of losing their properties.
  • The cellulose from which they are made is a natural source of fiber, which can support digestion and limit cholesterol absorption, meaning these capsules may have an additional, positive effect on the digestive system’s health.
  • Their plant origin makes them suitable for vegans and vegetarians, increasing their availability among those seeking products free of animal-derived ingredients.

Disadvantages of cellulose capsules

Despite their many advantages, cellulose capsules also have certain limitations. Their production cost is higher than that of gelatin capsules, which can affect the final price of supplements and medicines. In addition, due to their fibrous structure, their digestion time is longer, so people with sensitive digestive systems may experience minor discomfort.

Gelatin or cellulose capsules?

The decision to choose the appropriate capsule form depends on many factors, such as the rate of active substance release, resistance to moisture, dietary preferences, and production costs. Both gelatin and cellulose capsules have their advantages, so it is worth analyzing their properties before making a decision.

Gelatin capsules are known for their rapid dissolution in the digestive system, which favors quick release of active substances. Their smooth surface makes swallowing easier, while at the same time they provide effective protection of the contents from external factors. However, due to their animal-derived composition, they are not suitable for people on a plant-based diet.

An alternative is cellulose (HPMC) capsules, which, thanks to their plant origin, are used in products intended for vegans and vegetarians. They are also more resistant to high temperatures, but may show greater moisture permeability, which in some cases affects the stability of the substances they contain. The final choice of capsules should take into account not only consumer preferences but also the impact of the given form on the bioavailability of ingredients and their effectiveness. Moreover, the type of capsule can affect the cost of the final product, which matters both for manufacturers and for people deciding to purchase supplements or medications.